Psilocybin Clinical Efficacy for Depression

(published May 20211)
Phase II Trial: 24 patients with major depressive disorder, participants who received psilocybin-assisted therapy showed improvement in blinded clinician rated–assessed depression severity and in self-reported secondary outcomes through the one-month follow-up
Conclusion: Psilocybin was efficacious in producing large, rapid, and sustained antidepressant effects in patients with major depressive disorder

(published November 20212)
Phase IIB Trial: Randomised, controlled 233 patients with treatment resistant depression (TRD) received single dose of psilocybin; showed reduction in symptoms of depression at three weeks through to completion (12 weeks) vs. controls.
Safety: 90% of adverse events were mild or moderate
Conclusion: Psilocybin showed statistical efficacy in benefiting patients with treatment resistant depression
- JAMA Psychiatry. 2021;78(5):481-489. doi:10.1001/jamapsychiatry.2020.3285
- https://compasspathways.com/our-research/psilocybin-therapy/clinical-trials/psilocybin-therapy-study-results/
Psilocybin Headline Clinical Results
At Week 4
The benefit achieved with psilocybin treatment was approximately 4x greater than the effect with current depression treatments
Had a Clinically Significant Response to Psilocybin
Met the Criteria for Remission of Depression
- JAMA Psychiatry. 2021;78(5):481-489. doi:10.1001/jamapsychiatry.2020.3285
LSD Clinical Evidence

- LSD, classical hallucinogen, used recreationally since 1938, banned in 1968 in the US and other countries
- Considered to be non-addictive with low potential for abuse
- Evaluated in numerous academic studies, showing behavioural changes, as well as remission of psychiatric symptoms1
- LSD clinical studies showed therapeutic benefit maintained for >12 months after treatment
- Target indications include anxiety, PTSD and substance abuse
- https://www.frontiersin.org/articles/10.3389/fpsyt.2019.00943/full